Total synthesis of ecteinascidin 743 |
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| Authors: | Endo Atsushi Yanagisawa Arata Abe Masanao Tohma Shigemitsu Kan Toshiyuki Fukuyama Tohru |
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| Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. |
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