HDX Workbench: Software for the Analysis of H/D Exchange MS Data |
| |
Authors: | Bruce D Pascal Scooter Willis Janelle L Lauer Rachelle R Landgraf Graham M West David Marciano Scott Novick Devrishi Goswami Michael J Chalmers Patrick R Griffin |
| |
Institution: | Department of Molecular Therapeutics, The Scripps Research Institute-Scripps Florida, Jupiter, FL, 33458, USA. |
| |
Abstract: | Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu . |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|