| Synthesis and Characterizations of Some New Diacylhydrazones |
| |
| 作者姓名： | WANG Shu-Xiang
WANG Wei
LI Ji-Tai
LI Tong-Shuang |
| |
| 作者单位： | WANG,Shu-Xiang（College of Chemistry and Environmental Science, Hebei University, Baoding 071002）
WANG,Wei（College of Chemistry and Environmental Science, Hebei University, Baoding 071002）
LI,Ji-Tai（College of Chemistry and Environmental Science, Hebei University, Baoding 071002）
LI,Tong-Shuang（College of Chemistry and Environmental Science, Hebei University, Baoding 071002） |
| |
| 基金项目： | the Natural Science Foundation of Hebei Province，河北省自然科学基金 |
| |
| 摘 要： | Acylhydrazine and hydrazine are highly reactive chemicals that have a wide spectrum of uses such as in the chemical and pharmaceutical industries and as a fuel and propellant in aircraft, rockets and satellites. And they can react with microelement in the organism, so they were reported to possess different biological and pharmacological activities, such as antiphthistic, antitumour and so on. But, acylhydrazine and hydrazine have free group of NH2, so they usually have some toxicity to the organism. Hydrazones were investigated in view of the possibility of their being less toxic than the parent hydrazides, because of the blocking of the free NH2 group. In order to reduce the toxicity to the organism, people have been interested in the hydrazones compounds in recent years. In this work, 2,6-dimethylpyridine-3,5-diacylhydrazones were synthesized.
|
Synthesis and Characterizations of Some New Diacylhydrazones |
| |
| WANG,Shu-Xiang,WANG Wei,LI,Ji-Tai,LI,Tong-Shuang.Synthesis and Characterizations of Some New Diacylhydrazones[J].Chinese Journal of Organic Chemistry,2004,24(Z1):83. |
| |
| Authors: | WANG Shu-Xiang WANG Wei LI Ji-Tai LI Tong-Shuang |
| |
| Abstract: | Acylhydrazine and hydrazine are highly reactive chemicals that have a wide spectrum of uses such as in the chemical and pharmaceutical industries and as a fuel and propellant in aircraft, rockets and satellites. And they can react with microelement in the organism, so they were reported to possess different biological and pharmacological activities, such as antiphthistic, antitumour and so on. But, acylhydrazine and hydrazine have free group of NH2, so they usually have some toxicity to the organism. Hydrazones were investigated in view of the possibility of their being less toxic than the parent hydrazides, because of the blocking of the free NH2 group. In order to reduce the toxicity to the organism, people have been interested in the hydrazones compounds in recent years. In this work, 2,6-dimethylpyridine-3,5-diacylhydrazones were synthesized. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
|
