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小鼠自身玫瑰花环形成试验条件及带瘤小鼠自身花环形成率的动态变化
引用本文:马志章 ,丁仁瑞 ,金晓萍 ,江希明.小鼠自身玫瑰花环形成试验条件及带瘤小鼠自身花环形成率的动态变化[J].浙江大学学报(理学版),1988,15(3):333-338.
作者姓名:马志章  丁仁瑞  金晓萍  江希明
基金项目:中国科学院科学基金资助课题
摘    要:本文研究了小鼠淋巴细胞自身玫瑰花环(AR)形成试验的条件,证明淋巴细胞与红细胞的比例以7:10,37℃温育后4℃自然沉降,不需加小牛血清,用自体或同种异体红细胞皆较适宜.对比小鼠的胸腺细胞与脾脏淋巴细胞,两者AR形成率无显著差异.检测小鼠带瘤过程中AR形成率的动态变化,证明早期带瘤鼠AR的数量与正常鼠接近;带瘤中期AR的数量显著降低,带瘤晚期AR的数量与正常值之间仍表现显著差异,但不再继续下降,基本保持中期的水平.文章认为,AR可以作为机体带瘤的一个参考性测定指标.文内讨论了AR的形成细胞作为胸腺后前体细胞,它在带瘤时的动态变化与淋巴细胞不同亚群的比势变化之间存在一定关系.

关 键 词:自身玫瑰花环  肿瘤  小鼠

Studies on the Experimental Conditions for Autologous Rosette Formation Test and the Kinetic Variation of Autologous Rosette-lorming Cells of Tumor-bearing Mice
Ma Zhizhang Ding Renrui Jin Xiaoping Jiang Ximing.Studies on the Experimental Conditions for Autologous Rosette Formation Test and the Kinetic Variation of Autologous Rosette-lorming Cells of Tumor-bearing Mice[J].Journal of Zhejiang University(Sciences Edition),1988,15(3):333-338.
Authors:Ma Zhizhang Ding Renrui Jin Xiaoping Jiang Ximing
Institution:Ma Zhizhang Ding Renrui Jin Xiaoping Jiang Ximing
Abstract:In this paper, the kinetic variation of autologous rosette-forming cells (ARFC) value in tumor-bearing mice is studied. The experimental result has shown that the relative number of ARFC at the early stage of tumor-bearing approaches the value of normal mice. It decreases significantly at the middle stage of tumor-bearing, and it is still lower at the late stage than that of normal and that at the early stage, but it no longer significantly decreases continuously and retnains at the level of middle stage. It is indicated that the value of ARFC can be used as an available assay for tunior-bearing. The possibility of differentiation from ARFC (which are immature cells) into mature lyaiphocytes (Tr cell) during tumor progress is discussed.
Keywords:ARFC  tumor  mice
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