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| 钌配合物抗肿瘤研究新进展* | |
| 引用本文： | 陈禹,杜可杰,巢晖,计亮年.钌配合物抗肿瘤研究新进展*[J].化学进展,2009,21(5):836-844. |
| 作者姓名： | 陈禹 杜可杰 巢晖 计亮年 |
| 作者单位： | (中山大学化学与化学工程学院 生物无机与合成化学教育部重点实验室 广州 510275) |
| 基金项目： | 973项目;国家自然科学基金 |
| 摘 要： | 钌配合物作为抗癌药物的研究已受到广泛关注，成为无机药物化学的重要研究内容之一。本文简要评述了近年来钌配合物的抗肿瘤活性研究进展，包括作为细胞毒药物的钌配合物设计与筛选、钌配合物以端粒酶、DNA拓扑异构酶及蛋白激酶作为抗肿瘤作用新靶点等。 |
| 关 键 词： | 钌配合物 DNA 抗肿瘤 抑制 |
| 收稿时间： | 2009-02-02 |
| 修稿时间： | 2009-01-27 |
New Trends for Ruthenium Complexes with Anticancer Activity |
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| Chen Yu Du Kejie Chao Hui Ji Liangnian.New Trends for Ruthenium Complexes with Anticancer Activity[J].Progress in Chemistry,2009,21(5):836-844. | |
| Authors: | Chen Yu Du Kejie Chao Hui Ji Liangnian |
| Institution: | (School of Chemistry and Chemical Engineering, Laboratory of Bioinorganic and Synthetic Chemistry, Ministry of Education, Sun Yat-Sen University, Guangzhou 510275, China) |
| Abstract: | The study of ruthenium complexes as antitumor drugs has received intense interest and become an important research field of medicinal ionrganic chemistry. This review highlights some recent progresses in the antitumor activity of ruthenium complexes, including the design and screening of ruthenium complexes as cytotoxic drugs, and the inhibition of telomerase, topoisomerase and protein kinase with ruthenium complexes.
Contents 1 The antitumor activity of ruthenium complexes 1.1 KP1019-type complexes 1.2 NAMI-type complexes 1.3 Ruthenium(II)-arene complexes 1.4 Ruthenium polypyridyl complexes 2 Telomerase Inhibition 3 Topoisomerase Inhibition 4 Protein Kinase Inhibition 5 Prospect |
| Keywords: | ruthenium complexes DNA antitumor inhibition |
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