| 3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成 |
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| 引用本文： | 关玉昆,房丽晶,唐志勇,李裕林.3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成[J].高等学校化学学报,2007,28(7):1307-1309. |
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| 作者姓名： | 关玉昆 房丽晶 唐志勇 李裕林 |
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| 作者单位： | 1. 烟台大学药学院,烟台,264005;兰州大学功能有机分子化学国家重点实验室,兰州,730000
2. 兰州大学功能有机分子化学国家重点实验室,兰州,730000 |
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| 基金项目： | 国家自然科学基金
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烟台大学校科研和教改项目 |
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| 摘 要： | 报道了一种全合成3-氧-11,12,13-三羟基桉烷-4-烯(1)的简便方法. 对于该化合物及其衍生物的药理活性研究目前正在进行中.
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| 关 键 词： | 桉烷 3-氧-11 12 13-三羟基桉烷-4-烯 全合成 倍半萜 |
| 文章编号： | 0251-0790（2007）07-1307-03 |
| 收稿时间： | 2006-10-17 |
| 修稿时间： | 2006-10-17 |
Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene |
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| GUAN Yu-Kun,FANG Li-Jing,TANG Zhi-Yong,LI Yu-Lin.Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene[J].Chemical Research In Chinese Universities,2007,28(7):1307-1309. |
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| Authors: | GUAN Yu-Kun FANG Li-Jing TANG Zhi-Yong LI Yu-Lin |
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| Institution: | 1. School of Pharmacy, Yantai University, Yantai 264005, China; 2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | 3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity.For the purpose of pharmacological activity research on natural product 1 and its derivatives,a facile total synthesis of compound 1 starting from( )-dihydrocarvone(2) was completed in an overall yield of 24%.The structures of all intermediates and product 1 were confirmed via 1H NMR,13C NMR,MS and IR techniques.The NMR data of compound 1 are in agreement with those of natural products. |
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| Keywords: | Eudesmane 3-Oxo-11 12 13-trihydroxyeudesm-4-ene Total synthesis Sesquiterpene |
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