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Characteristics of polyurethane-based sustained release membranes for drug delivery |
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| Authors: | Mihaela Mândru Constantin Ciobanu Stelian Vlad Maria Butnaru Laurent Lebrun Marcel Popa | |
| Institution: | 1. Faculty of Chemical Engineering and Environmental Protection, ”Gh. Asachi” Technical University, 700050, Iasi, Romania 2. “Petru Poni” Institute of Macromolecular Chemistry, 700487, Iasi, Romania 3. Faculty of Medical Bioengineering, Gr.T.Popa” University of Medicine and Pharmacy, 700115, Iasi, Romania 4. University of Rouen UMR 6270 CNRS, Polymers, Biopolymersm, Surfaces, 76821, Mont Saint Aignan Cedex, France |
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| Abstract: | This paper is focused on the preparation and physicochemical characterization of two poly(ester ether urethane)s with rifampicin in their matrix and different molar concentrations of urethane groups. The polyurethanes with rifampicin were processed as asymmetrical microporous membranes by a phase inversion method and characterized by attenuated total reflection — Fourier transform infrared (ATR-FTIR) spectroscopy and differential scanning calorimetry (DSC). The influence of the surface morphology in the release of drug compounds was analyzed by scanning electron microscopy (SEM), atomic force microscopy (AFM), contact angle, and water uptake. The release of rifampicin depends on the molar concentration of urethane groups and also on the surface morphology of the polyurethane membranes. The antibacterial activity was evaluated with S. Epidermidis RP 62 A and P. Aeruginosa ATCC 1544. Finally, the biocompatibility of the polyurethane membranes was studied with human dermal fibroblasts (HDF) to evaluate the potential biomedical applications.  | |
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