| 层层组装构建抗凝血和内皮细胞化协同功能界面 |
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| 引用本文： | 林全愧,阎嘉洁,计剑,沈家骢.层层组装构建抗凝血和内皮细胞化协同功能界面[J].高等学校化学学报,2009,30(6):1256. |
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| 作者姓名： | 林全愧 阎嘉洁 计剑 沈家骢 |
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| 作者单位： | 浙江大学高分子科学与工程学系, 教育部高分子合成与功能构造重点实验室, 杭州 310027 |
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| 基金项目： | 国家"八六三"计划，国家"九七三"计划，浙江省科技计划，吉林大学超分子结构与材料国家重点实验室开放课题基金 |
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| 摘 要： | 本文采用天然细胞外基质组分、强抗凝血活性的肝素和促细胞黏附生长的胶原蛋白, 在不锈钢支架表面构建肝素/胶原多层膜, 探索利用层层组装多层膜所显示出的协同效应, 实现抗凝血和促进内皮细胞生长的协同功能, 为改善心血管支架抗凝血和抗再狭窄修饰寻求新方法.
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| 关 键 词： | 层层组装 细胞外基质 抗凝血 细胞相容性 |
| 收稿时间： | 2008-12-11 |
Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification |
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| LIN Quan-Kui,YAN Jia-Jie,JI Jian,SHEN Jia-Cong.Natural Anticoagulant and Endothelial Cell-Compatible Multilayer for Endovascular Stents Surface Modification[J].Chemical Research In Chinese Universities,2009,30(6):1256. |
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| Authors: | LIN Quan-Kui YAN Jia-Jie JI Jian SHEN Jia-Cong |
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| Institution: | Department of Polymer Science and Engineering, Key Laboratory of Macromolecule Synthesis and Functionalization of Minster of Education, Zhejiang University, Hangzhou 310027, China |
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| Abstract: | Thrombosis and in-stent restenosis constitute major clinical failures of endovascular stent implantation.In this research,a polyelectrolyte multilayered film of heparin/collagen was constructed onto the endovascular stent via layer-by-layer deposition.The in vitro human platelet adhesion test and blood clotting time assessments demonstrated that the fabricated multilayer took on excellent hemocompatibility.The in vitro human umbilical vein endothelial cell culture results show that the endothelial cell adhe... |
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| Keywords: | Layer-by-layer Extracellular matrix Anti-thrombosis Cytocompatibility |
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