Konformationsanalysen von Modell-Tripeptiden: Der Einfluss von α,α-disubstituierten α-Aminosäuren auf die Sekundärstruktur. Teil I. NMR- und CD-Untersuchungen |
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| Authors: | Peter Wipf Heinz Heimgartner |
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| Institution: | Organisch-chemisches Institut der Universität Zürich, Winterthurerstr. 190, CH–8057 Zürich
Teil der Dissertation von P.W., Universität Zürich, 1987. |
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| Abstract: | Conformational Analysis of Tripeptide Models: The Influence of α,α-disubstituted α-Amino Acids on the Secondary Structure. NMR and CD Investigations The conformational properties of α,α-disubstituted α-amino acids are discussed on the basis of NMR, CD, X-ray, and molecular-mechanics studies on tripeptide models 1 . It is shown that different disubstituted amino acids do not exert the same influence on secondary-structure formation. Thus, the choice of substituents allows the construction and stabilisation of different conformations of oligopeptide chains. |
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