| 4-芳氨基-6,7-二甲氧基喹唑啉的合成及生物活性研究 |
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| 引用本文： | 王孝妹,刘小莉,张喜全,顾红梅,徐宏江,王留昌,李宝林.4-芳氨基-6,7-二甲氧基喹唑啉的合成及生物活性研究[J].化学研究与应用,2011,23(3):317-321. |
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| 作者姓名： | 王孝妹 刘小莉 张喜全 顾红梅 徐宏江 王留昌 李宝林 |
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| 作者单位： | 1. 教育部药用资源与天然药物化学重点实验室,陕西师范大学化学与材料科学学院,陕西,西安,710062
2. 江苏正大天晴药业股份有限公司,江苏,南京,210042 |
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| 基金项目： | 国家自然科学基金资助项目，陕西师范大学理工科中央高校基本科研业务费专项资助项目 |
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| 摘 要： | 以4-氯-6,7-二甲氧基喹唑啉和4-(2-芳基)乙烯基苯胺或4-2-(2-呋喃基)]乙烯基苯胺为原料合成了5种4-芳氨基-6,7-二甲氧基喹唑啉类化合物.利用IR、NMR和元素分析等表征手段对其进行了结构确认.这5种化合物对HT-29和MDA-MB-231两种细胞模型的体外抗癌活性测试结果表明,部分化合物具有良好的...
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| 关 键 词： | 喹唑啉类化合物 抗肿瘤活性 合成 |
Synthesis and bioactivity of 4-arylamino-6,7-dimethoxyl quinazoline derivatives |
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| WANG Xiao-mei,LIU Xiao-li,ZHANG Xi-quan,GU Hong-mei,XU Hong-jiang,WANG Liu-chang,LI Bao-lin.Synthesis and bioactivity of 4-arylamino-6,7-dimethoxyl quinazoline derivatives[J].Chemical Research and Application,2011,23(3):317-321. |
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| Authors: | WANG Xiao-mei LIU Xiao-li ZHANG Xi-quan GU Hong-mei XU Hong-jiang WANG Liu-chang LI Bao-lin |
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| Institution: | WANG Xiao-mei1,LIU Xiao-li1,ZHANG Xi-quan2,GU Hong-mei2,XU Hong-jiang2,WANG Liu-chang1,LI Bao-lin1(1.Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry,School of Chemistry and Materials Science,Shaanxi Normal University,Xi'an 710062,China,2.Jiangsu Chia Tai Tianqing Pharmaceutical Co.,Ltd.,Nanjing 210042,China) |
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| Abstract: | Five 4-arylamino-6,7-dimethoxyl quinazoline derivatives were synthesized from 4-chloro-6,7-dimethoxyl quinazoline and 4-(2-arylethenyl)aniline or 4-2-(2-furyl)ethenyl]aniline.The structures of the five compounds were characterized by elemental analysis,IR and NMR spectra.Bioactivities of the new compounds were tested.The results showed that some of them possessed benign anti-cancer activity to HT-29,MDA-MB-231 cells. |
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| Keywords: | quinazoline derivatives anti-tumor activity synthesis |
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