| 人红细胞摄入Cd2+离子的动力学和机理 |
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| 引用本文： | 吴刚,李荣昌,齐秀文,王夔.人红细胞摄入Cd2+离子的动力学和机理[J].无机化学学报,2000,16(2):279-286. |
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| 作者姓名： | 吴刚 李荣昌 齐秀文 王夔 |
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| 作者单位： | [1]包头医学院 [2]新疆石河子大学医学院 |
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| 基金项目： | 国家自然科学基金(No.29571007) |
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| 摘 要： | 不同Cd2+离子浓度引起的人红细胞相对溶血率及临界溶血浓度CH0已经测定,CH0=2.5×10-4mol·L-1。Cd2+跨膜进入人红细胞遵从一级动力学过程,其一级速率常数为1.2×10-2h-1。阴离子通道抑制剂DIDS及K+,Na+-ATPase抑制剂均可部分抑制人红细胞摄入Cd
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| 关 键 词： | 镉 细胞摄取 人 红细胞 |
| 收稿时间： | 1999/12/23 0:00:00 |
| 修稿时间： | 1999-12-23 |
Kinetics and Mechanisms of the Uptake of Human Erythrocytes for Cd 2+ Ions |
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| WU Gang,LI Rong-Chang,QIAO Xiu-Wen and WANG Kui.Kinetics and Mechanisms of the Uptake of Human Erythrocytes for Cd 2+ Ions[J].Chinese Journal of Inorganic Chemistry,2000,16(2):279-286. |
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| Authors: | WU Gang LI Rong-Chang QIAO Xiu-Wen and WANG Kui |
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| Institution: | Department of Bioinorganic and Inorganic Drug Chemistry, Beijing Medical University, Beijing 100083,Department of Bioinorganic and Inorganic Drug Chemistry, Beijing Medical University, Beijing 100083,Department of Bioinorganic and Inorganic Drug Chemistry, Beijing Medical University, Beijing 100083 and Department of Bioinorganic and Inorganic Drug Chemistry, Beijing Medical University, Beijing 100083 |
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| Abstract: | The Cd 2+-induced relative hemolysis rate and critical hemolysis concentration(CH0) of human erythrocythes were determined, CH0 is 0.25mmol·L-1. The uptake of human erythrocythes for Cd 2+ followed a first order kinetic process with rate constant k =1.2×10-2 h-1. DIDS and Oubain, the former is inhibitor of anion channel and the latter is of Na+, K+ ATP ase, all inhibited partly the cellular uptake of Cd 2+. The concentration of Cl- and pHvalues in medium effected the cellular uptake. The uptake amount of Cd increased lineally with concentrations of Cd2+ outside the cells. These results indicated that the uptake of human erythrocytes for Cd 2+ is a complex process involving simple passive diffusion, carrier transfer through aniom channel and active transport. |
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| Keywords: | cadmium cellular uptake human erythrocytes |
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