| 水杨酸金属配合物与牛血清白蛋白的相互作用 |
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| 引用本文： | 刘 哲,王坤杰,董银龙,宋玉民. 水杨酸金属配合物与牛血清白蛋白的相互作用[J]. 无机化学学报, 2010, 26(1): 72-78 |
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| 作者姓名： | 刘 哲 王坤杰 董银龙 宋玉民 |
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| 作者单位： | 西北师范大学化学化工学院,兰州,730070 |
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| 基金项目： | 甘肃省自然科学基金项，甘肃省高分子材料重点实验室项目资助 |
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| 摘 要： | 本文采用荧光法研究了水杨酸金属配合物与牛血清白蛋白的相互作用。观察到水杨酸金属配合物对牛血清白蛋白荧光产生猝灭现象,猝灭方式为静态猝灭。计算了结合常数和结合位点数。并且用圆二色谱法研究水杨酸金属配合物对牛血清白蛋白二级结构的影响,发现水杨酸金属配合物的存在明显改变牛血清白蛋白的构象。
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| 关 键 词： | 水杨酸金属配合物； 牛血清白蛋白； 荧光光谱； 圆二色谱 |
Interaction between Metal Complexes of Salicylic Acid and Bovine Serum Albumin |
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| LIU Zhe,WANG Kun-Jie,DONG Yin-Long and SONG Yu-Min. Interaction between Metal Complexes of Salicylic Acid and Bovine Serum Albumin[J]. Chinese Journal of Inorganic Chemistry, 2010, 26(1): 72-78 |
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| Authors: | LIU Zhe WANG Kun-Jie DONG Yin-Long SONG Yu-Min |
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| Affiliation: | College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070,College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070,College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070 and College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070 |
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| Abstract: | In this paper, the interaction between bovine serum albumin and metal complexes of salicylic acid has been studied by fluorescence spectroscopy. It was observed that metal complexes of salicylic acid can reduce the fluorescence intensity of bovine serum albumin. The way of fluorescence quenching was static quenching, and then calculated the binding constant and binding sites. And use the circular dichroism method to study the impact of salicylic acid metal complexes on the secondary structure of bovine serum albumin, and found that salicylic acid metal complexes has obviously changed the conformation of bovine serum albumin. |
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| Keywords: | salicylic acid metal complexes bovine serum albumin fluorescence circular dichroism |
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