An expedient synthesis of ferrocene grafted spirooxindolopyrrolizidines via [3+2]-cycloaddition of azomethine ylides |
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| Authors: | AR Suresh Babu Sundari Baskaran |
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| Institution: | a Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600025, India
b Department of Physics, Queen Mary's College, Chennai 600005, India |
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| Abstract: | A facile and rapid one-pot synthesis of ferrocene bearing novel spiropyrrolizidines has been accomplished by 3+2]-cycloaddition reaction of various azomethine ylides derived from isatin/5,7-dibromoisatin and l-proline with various ferrocene derivatives as dipolarophile in good yield. The protocol is general and applicable to a wide variety of ferrocenyl derived dipolarophiles. Effect of various solvents on 3+2]-dipolar cycloaddition reaction is also studied. |
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| Keywords: | Ferrocene Cycloaddition Azomethine ylide Spiroheterocycles Oxindolopyrrolizidines |
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