General approach to 6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-ones via nucleophile-mediated ring expansion of tetrahydropyrimidines |
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| Authors: | Anastasia A. Fesenko |
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| Affiliation: | Department of Organic Chemistry, Moscow State Academy of Fine Chemical Technology, 86 Vernadsky Avenue, 119571 Moscow, Russian Federation |
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| Abstract: | A general six-step approach to 6-tosyl-2,3,4,5-tetrahydro-1H-1,3-diazepin-2-ones has been developed. The key step involves a ring expansion reaction of 4-mesyloxymethyl- or 4-tosyloxymethyl-5-tosyl-1,2,3,4-tetrahydropyrimidin-2-one mediated by nucleophilic reagents. |
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| Keywords: | 1,2,3,4-Tetrahydropyrimidin-2-ones 2,3,4,5-Tetrahydro-1H-1,3-diazepin-2-ones Ring expansion |
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