Synthesis of 7-deoxycholic amides or cholanes containing distinctive ion-recognizing groups at C3 and C12 and evaluation for ion-selective ionophores |
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Authors: | Jeung Hoon On Byeong Hyo Kim |
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Institution: | Department of Chemistry, Kwangwoon University, Seoul 139-701, Republic of Korea |
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Abstract: | Tweezer-type ionophores containing C3-bipyridyl and C12-dithiocarbamoyl groups, or C3-bithiophenyl with C12-dithiocarbamoyl groups on a 7-deoxycholic amide or cholane derivatives were designed and synthesized. Potentiometric evaluation of the PVC membranes containing those deoxycholic amides/cholanes linked with unsymmetrically substituted tweezer-type bipyridyl or bithiophenyl with dithiocarbamoyl moieties proved their good affinity and selectivity for silver(I) ion. Especially, ionophores with bithiophenyl moiety on the 3α-position and diphenylaminothioxomethylthioacetyloxy group on 12α-position of cholan-24-amide or cholane reveal the most excellent result with a theoretical slope value of 59 mV/decade. |
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