Preparation of Sn-β-alanine: A new freeze-dried kit to be labelled with99mTc for liver scintigraphy |
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Authors: | A K Jabbar H M A Karim M A A Al-Janabi |
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Institution: | (1) Radioisotope Production Department, Nuclear Research Centre, Tuwaitha, Baghdad, (Iraq) |
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Abstract: | Sn-alanine kits were prepared in lyophilized form containing 7.02·10–2 M -alanine and 5.5·10–4M stannous chloride dihydrate. The optimal pH value of the preparation was found to be equal to 4.3–5.1. The radiochemical purity and the stability of99mTc-alanine were assessed by gel filtration column scanning techniques (GCS) and thin layer chromatography, and the labelling yield of the complex was higher than 95%. The organ distribution data in mice showed that more than 90% of the injected dose had been accumulated in the liver. However, a negligible amount of radioactivity was detected in the non-target organs. The stability of99mTc-alanine was followed for 5 hours and the Sn-alanine kit was stable for at least 3 months. |
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