The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles |
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Authors: | Migliorini Antonella Oliviero Chiara Gasperi Tecla Loreto Maria Antonietta |
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Institution: | Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, I-00185 Roma, Italy. |
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Abstract: | The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules. |
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