Ligational behaviour of two biologically active N−S donors towards cobalt(III), iron(III), iron(II) and rhodium(III)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Ligational behaviour of two biologically active N−S donors towards cobalt(III), iron(III), iron(II) and rhodium(III)

Authors:	Shyamal Kumar Chattopadhyay Mosarraf Hossain Saktiprosad Ghosh Arur Kumar Guha

Institution:	(1) Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, 700032 Calcutta, India;(2) Department of Biological Chemistry, Indian Association for the Cultivation of Science, 700032 Calcutta, India;(3) Present address: Department of Chemistry, Bengal Engineering College, 711103 Howrah, West Bengal

Abstract:	Summary The chelating behaviour of two biologically active ligands, pyridine-2-carboxaldehyde(4-phenyl) thiosemicarbazone(L₁H) and pyridine-2-carboxaldehyde thiosemicarbazone(LH), towards Fe^III, Co^III, Fe^II and Rh^III has been investigated. The ligands act as tridentate N–N–S donors, resulting in the formation of bis-chelate complexes of the type M^III(A)₂X·nH₂O (A=L₁ or L; X=Cl, ClO₄; M=Co^III, Rh^III, Fe^III), Fe^II(L₁H)₂SO₄·2H₂O and Fe^II(L₁)₂·H₂O. Biological activity of the ligands and the metal complexes in the form ofin vitro antibacterial activities towardsE. coli has been evaluated and the possible reasons for enhancement of the activity of ligands on coordination to metal ion is discussed.

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