Study on novel hydrogels based on thermosensitive PNIPAAm with pH sensitive PDMAEMA grafts |
| |
| Authors: | Wang Zong-Chun Xu Xiao-Ding Chen Chang-Sheng Wang Gan-Rui Wang Bo Zhang Xian-Zheng Zhuo Ren-Xi |
| |
| Institution: | aKey Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China;bDepartment of Pharmacy, The Renmin Hospital of Wuhan University, Wuhan 430060, PR China |
| |
| Abstract: | A series of novel hydrogels based on poly(N-isopropylacrylamide) (PNIPAAm) with pendant poly(N-(2-(dimethylamino) ethyl)-methacrylamide) (PDMAEMA) grafts were designed and synthesized. The influence of the pendant PDMAEMA grafts on the properties of the resulted hydrogels was examined in terms of morphology observed by scanning electron microscopy (SEM), thermal property characterized by differential scanning calorimetry (DSC) and shrinking/swelling kinetics upon external temperature changes. In comparison with the conventional PNIPAAm hydrogels, resulting hydrogels presented favorable pH sensitivity as well as improved thermosensitive properties, including enlarged water containing capability at room temperature and faster shrinking/swelling rate upon heating. In addition, fish DNA, used as a model drug, was loaded into the hydrogels, and the controlled release behavior of the drug-loaded hydrogels at different temperatures (22 and 37 °C) was further studied. |
| |
| Keywords: | PNIPAAm hydrogel Pendant PDMAEMA Thermosensitive pH sensitive Controlled release |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
