| Synthesis of Analogues of the Antitumor （1→6）-Branched （1→3）-Glucohexaose |
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| 引用本文： | 曾佑林,张建军,孔繁祚.Synthesis of Analogues of the Antitumor （1→6）-Branched （1→3）-Glucohexaose[J].中国化学,2004,22(5):460-466. |
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| 作者姓名： | 曾佑林 张建军 孔繁祚 |
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| 作者单位： | ResearchCenterforEco-EnvironmentalSciences,ChineseAcademyofSciences,Beijing100085,China |
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| 基金项目： | Project supported by Chinese Academy of Sciences (No. KZCX3-J-08) and the National Science Foundation of China (Nos. 30070185 and 39970964). |
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| 摘 要： | β-D-Glcp-(1→）3-β-D-Glcp-(1→6)-]α-D-Manp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp(1→6)-]D-Glcp(18)and β-D-Glcp(1→3)-β-D-Glcp(1→6)-]α-D-Manp-(1→3)-β-D-Glcp(1→3)-β-D-Glcp(1→6)-]β-D-Glcp-D-(1→3)-Glcp-1→OM3(29)were synthesized as the analogues of the immunomodulator β-D-Glcp-(1→3)-β-D-Glcp(1→6)-]α-D-Glcp(1→3)-β-D-Glcp(1→63)-β-D-Glcp(1→6)-]D-Glcp through coupling of trisaccharide donors 9 with trisaccharide acceptor 16 and tetrasaccharide acceptor 27 followed by deprotection,respectively.
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| 关 键 词： | 立体选择性合成 寡糖 三氯亚氨逐乙酸酯 免疫调节剂 抗菌活性 多糖 |
Synthesis of Analogues of the Antitumor (1→6)‐Branched (1→3)‐Glucohexaose |
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| ZENG,You-Lin ZHANG,Jian-Jun KONG,Fan-Zuo Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing ,China.Synthesis of Analogues of the Antitumor (1→6)‐Branched (1→3)‐Glucohexaose[J].Chinese Journal of Chemistry,2004,22(5):460-466. |
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| Authors: | ZENG You-Lin ZHANG Jian-Jun KONG Fan-Zuo Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing China |
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| Institution: | ZENG,You-Lin ZHANG,Jian-Jun KONG,Fan-Zuo* Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China |
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| Abstract: | b-D-Glcp-(13)-b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-b-D-Glcp-(16)-]D-Glcp (18) and b-D-Glcp-(13)-b-D-Glcp-(16)-]a-D-Manp-(13)-b-D-Glcp-(13)-b-D-Glcp-(16)-]b-D-Glcp-D-(13)-Glcp-1OMe (29) were synthesized as the analogues of the immunomodulator b-D-Glcp-(13)-b-D-Glcp- (16)-]a-D-Glcp-(13)-b-D-Glcp-(13)-b-D-Glcp-(16)-]D-Glcp through coupling of trisaccharide donors 9 with trisaccharide acceptor 16 and tetrasaccharide acceptor 27 followed by deprotection, respectively. |
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| Keywords: | oligosaccharide trichloroacetimidate regio- and stereoselective synthesis |
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