Novel synthetic method for allylic amination of cyclic allylic ethers using chlorosulfonyl isocyanate |
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| Authors: | Sang Hwi LeeIn Su Kim Qing Ri LiGuang Ri Dong Young Hoon Jung |
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| Affiliation: | a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
b Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea |
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| Abstract: | The introduction of amines to allylic or benzylic position of cyclic compounds with chlorosulfonyl isocyanate is developed in high to excellent yields. This method provides a novel access to biologically active compounds including the framework of 1-aminoindanes, 1-aminotetralines, and 1-amino-2-hydroxy cyclic compounds. Mechanistic evidence for the reaction pathway is also provided. |
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| Keywords: | Chlorosulfonyl isocyanate Amination Allylic ether Allylic carbamate 1-Aminoindane 1-Aminotetraline |
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