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Copper-catalyzed oxidative trifluoromethylation of benzylic sp C-H bond adjacent to nitrogen in amines |
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| Authors: | Hiromasa Mitsudera Chao-Jun Li |
| Affiliation: | a Department of Chemistry and FQRNT Center for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6 b Agric. Chem. Res. Lab., Sumitomo Chem. Co., Ltd, 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan |
| Abstract: | Copper-catalyzed trifluoromethylation via oxidative sp3 C-H activation at the α-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-90% yields under mild conditions. |
| Keywords: | C-H functionalization Copper-catalyzed Fluorination Oxidative coupling Heterocycle |
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