Biomedical Application of an Isotope Selective Nondispersive Infrared Spectrometer for 13CO2 and 12CO2 Concentration Measurements in Breath Samples |
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| Authors: | M. Haisch P. Hering P. Schadewaldt H. Brösicke B. Braden S. Koletzko |
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| Affiliation: | 1. Institut für Lasermedizin der Universit?t , Düsseldorf;2. Max-Planck-Institut für Quantenoptik , Garching;3. Diabetes Forschungsinstitut , Düsseldorf;4. Kinderklinik der FU Berlin;5. Abteilung Gastroenterologie , Universit?tsklinikum, Frankfurt;6. Kinderpoliklinik der LMU , München |
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| Abstract: | A newly developed isotope selective nondispersive infrared (NDIR) spectrometer for the measurement of 13CO2 and 12CO2 concentrations in breath samples was applied as a low cost and very simple to operate alternative to isotope ratio mass spectrometry (IRMS). We used this device for several biomedical applications ([13C]urea breath test, [13C]leucine metabolism, [13C]methacetin catabolism of rats) and found that the results agree very well with IRMS. |
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| Keywords: | Breath test carbon 13 13CO2 Helicobacter pylori [13C]leucine [13C]urea [13C]-methacetin isotope selective nondispersive infrared spectroscopy |
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