Periconones B-E,new meroterpenoids from endophytic fungus Periconia sp. |
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| Authors: | Ji-Mei Liu De-Wu Zhang Min Zhang Ri-Dao Chen Zheng Yan Jian-Yuan Zhao Jin-Lian Zhao Nan Wang Jun-Gui Dai |
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| Institution: | a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peaking Union Medical College, Beijing 100050, China |
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| Abstract: | Periconones B-E (1-4), four new polyketide-terpenoid hybrid molecules were isolated from the endophytic fungus Periconia sp. F-31. Their structures and absolute configurations were established by extensive spectroscopic data analysis and electronic circular dichroism (ECD). Compound 4 exhibited in vitro cytotoxic activity against the human MCF-7 tumor cell line with an IC50 value of 4.2 μmol/L, and compound 1 displayed anti-HIV activity with an IC50 value of 18.0 μmol/L. |
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| Keywords: | Meroterpenoids Periconia Endophytic fungus Annona muricata Periconone |
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