Intercalation assembly of kojic acid into Zn-Ti layered double hydroxide with antibacterial and whitening performances |
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Authors: | Xin-Rui Wang Hui-Min Cheng Xue-Wei Gao Wei Zhou Shu-Jing Li Xue-Li Cao Dongpeng Yan |
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Institution: | Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China; Department of Chemistry, Beijing Normal University, Beijing 100875, China |
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Abstract: | A melanin synthesis inhibitor and bacteriostatic agent, kojic acid (KA) has been intercalated into Zn-Ti layered double hydroxide (LDH) by an anion-exchange reaction. The structure and the thermal stability of the samples were characterized by XRD, FT-IR, TG-DTA and SEM. The study of KA release from ZnTi-KALDH in phosphate buffered solution (pH 5) implies that ZnTi-KA-LDH is a better controlled release system than pure KA. Meanwhile, the mechanisms of slow release were assessed by using four commonly kinetic models. The antimicrobial activity of ZnTi-KA-LDH was tested against three kinds of bacteria. The inhibition of L-dopa oxidation was tested to verify its skin whitening effect. The studies suggest that the kojic acid intercalated LDHs has the potential application as a safely functional composite in cosmetic. |
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Keywords: | Layered double hydroxide Kojic acid Intercalation Slow release Antimicrobial Tyrosinase |
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