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Diastereo- and enantioselective palladium-catalyzed dearomative [4+2] cycloaddition of 3-nitroindoles |
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| Authors: | Jia-Jia Suo Juan Du Yang-Jie Jiang Di Chen Chang-Hua Ding Xue-Long Hou |
| Affiliation: | a State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), Shanghai 200032, China;b Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China;c Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, SIOC, CAS, Shanghai 200032, China |
| Abstract: | Pd-catalyzed asymmetric decarboxylative [4 + 2] cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach. The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo- and enantioselectivities. |
| Keywords: | Palladium [4 + 2] cycloaddition Asymmetric catalysis 3-Nitroindole Vinyl benzoxazinanone |
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