N-Methyl substituted 2',4'- BNANC: a highly nuclease-resistant nucleic acid analogue with high-affinity RNA selective hybridization |
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| Authors: | Miyashita Kazuyuki Rahman S M Abdur Seki Sayori Obika Satoshi Imanishi Takeshi |
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| Institution: | Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. imanishi@phs.osaka-u.ac.jp. |
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| Abstract: | Oligonucleotides modified with a novel BNA analogue, 2', 4'-BNA(NC)N-Me], were synthesized, and in comparison to 2',4'-BNA (LNA), have similarly high RNA affinity, better RNA selectivity and much higher resistance to nuclease degradation, suggesting that the novel BNA analogue may be particularly useful for antisense approaches. |
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