Synthesis of Some New Thiazole,Oxazole, Pyrimidine and Pyridazine Derivatives from 2‐cyano‐N‐octadecyl‐acetamide as Antimicrobial and Surface Active Agents |
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| Authors: | Refat El‐Sayed Saleh A Ahmed |
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| Institution: | 1. Chemistry Department, College of Applied Sciences, Umm Al‐Qura University, Makkah, Saudi Arabia;2. Chemistry Department, Faculty of Science, Benha University, Benha, Egypt;3. Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt |
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| Abstract: | The motivation behind the present work is to synthesize some nonionic surfactants containing heterocyclic nucleus with intermediate fatty compounds for improving their surfactants properties. 2‐Cyano‐N‐octadecylacetamide was utilized as key intermediate for the synthesis of some new thiazole, pyrazole, oxazole, pyrimidine, 1,3‐dithiolane, thiophene, coumarin, oxazine and pyridazine derivatives. The newly synthesized compounds undergo propoxylation using propylene oxide to afford nonionic surface active agents. The antimicrobial and surface activities were evaluated and characterized through investigations of their spreading behavior in monolayer on water. |
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