Synthesis,Anti‐Microbial,and Cytotoxic Activities Evaluation of Some New Pyrido[2,3‐d]Pyrimidines |
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| Authors: | Samir Kamel Elsaedany Mohamed AbdEllatif Zein Elsayed Mohmoud AbedelRehim Reda Mohammed Keshk |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt;2. Department of Chemistry, Faculty of Science, Damnhour University, Damnhour, Egypt |
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| Abstract: | Novel pyridine derivatives 1d and 7 , pyrido2,3‐d]pyrimidine derivatives 2a , 2b , 2c , 2d , 3a , 3b , 3c , 3d , 4a , 4b , 4c , 4d , 5a , 5b , 5c , 5d , 6a , 6b , 6c , 6d , 8a , 8b , and 9a , 9b were synthesized and screened for their anti‐microbial and cytotoxic activities. Compounds 2b , 2c , 3b , 3c , 5b , 5c , 6b , 6c , and 7 showed excellent anti‐microbial activities against all the tested bacteria and fungi compared to the reference drugs. Furthermore, they exhibited high safety profile in cytotoxicity test except 2c and 3c . The structures of the newly synthesized compounds were confirmed by spectral data and elemental analysis. |
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