Synthesis of new amides of the <Emphasis Type="Italic">N</Emphasis>-methylpiperazine series |
| |
Authors: | E V Koroleva K N Gusak Zh V Ignatovich A L Ermolinskaya |
| |
Institution: | 1.Institute of New Materials Chemistry,National Academy of Sciences of Belarus,Minsk,Belarus |
| |
Abstract: | New carboxylic acid amides containing an N-methylpiperazine fragment were synthesized by reactions of 1-methylpiperazine or 3- and 4-(4-methylpiperazin-1-ylmethyl)aniline
with 4-chlorobenzoyl chloride and of 4-methyl-3-nitroaniline with 4-(4-methylpiperazin-1-ylmethyl)benzoyl chloride or benzotriazol-1-yl
4-(4-methylpiperazin-1-ylmethyl)benzoate. 4-Chloro-N-4-(4-methylpiperazin-1-ylmethyl)phenyl]benzamide reacted with imidazole, quinolin-5-amine, and 2-methylquinolin-5-amine
to give substituted 4-amino-N-4-(4-methylpiperazin-1-ylmethyl)phenyl]benzamides. 4-Methyl-3-nitrophenyl-4-methylpiperazin-1-yl-substituted benzamides
were reduced with hydrazine hydrate over Raney nickel to obtain N-(3-amino-4-methylphenyl)-4-(4-methylpiperazin-1-ylmethyl)benzamide as key intermediate in the synthesis of antileukemic agent
imatinib and its isomer with alternative position of the amide group, 4-(3-amino-4-methylphenylamino)methyl]phenyl-(4-methylpiperazin-1-yl)methanone. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|