The small peptide-catalyzed direct asymmetric aldol reaction in water |
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| Authors: | Dziedzic Pawel Zou Weibiao Háfren Jonas Córdova Armando |
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| Institution: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden. |
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| Abstract: | Simple modular di- and tripeptides with a primary amine at the N-terminus catalyze the aqueous asymmetric aldol reaction between unmodified ketones and aldehydes to furnish the corresponding beta-hydroxy ketones with up to 86% ee in water and 99% ee in aqueous media. |
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