Synthesis of new dihydropyrazines with DNA strand-breakage activity |
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| Authors: | Maruoka Hiroshi Kashige Nobuhiro Miake Fumio Yamaguchi Tadatoshi |
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| Institution: | Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. maruoka@fukuoka-u.ac.jp |
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| Abstract: | Treatment of 1,2-cyclohexanedione with 1,2-diamines, e.g. ethylenediamine and cis-(and trans-)1,2-diaminocyclohexane, caused 4+2] cyclocondensation to give the corresponding dihydropyrazine derivatives (compounds 1-6). They exhibited stronger DNA strand-breakage activity than that of dihydropyrazines, which has already been reported in previous papers. |
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