An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose |
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| Authors: | Hong Joon Hee Shim Myung Jung Ro Bong Oh Ko Ok Hyun |
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| Affiliation: | College of Pharmacy and College of Education, Chosun University, Kwangju 501-759, South Korea. hongjh@mail.chosun.ac.kr |
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| Abstract: | This paper describes an efficient synthetic route for various types of novel carbocyclic nucleosides. The required stereochemistry of the targeted nucleosides was successfully obtained with use of Grubbs cyclization and Trost allylic alkylation from the carbohydrate chiral template "D-lactose". |
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