三元交联剂分子烙印手性固定相

采用２－乙烯基吡啶＋丙烯酰胺复合功能单体，以三甲氧基丙烷三甲基丙烯酸酯为三元交联剂制备了苯甲氧羰基－Ｌ－色氨酸烙印手性固定相，并与二元交联剂烙印相同氨基酸衍生物的情况进行了对比，发现三元交联剂在较小的用量下就可使分子烙印聚合物达到足够的交联度，实现烙印分子对映体的基线分离。

Tribasic Cross-linker Molecular Imprinted Chiral Stationary Phase

Molecular imprinted polymers against N-Cbz-L-Trp utilizing 2-VP + AM as combined functional monomer and trimethylolpropane trimethacrylate (TRIM) as tribasic cross-linker were prepared and evaluated in HPLC mode.Comparing with molecular imprinted polymer (MIP) utilizing ethylene glycoldimethacrylate (EDMA) as cross-linker, it was found that MIP utilizing TRIM as cross-linker showed higher cross-link intensity and baseline chiral Separation of the template enantiomer was achieved on a shorter column. More functional monomers were used and more template molecules were imprinted in the MIP utilizing TRIM as cross-linker. This could result in more recognition cavities in the polymer and the number of the imprinted cavities in unit weight of chiral stationary phase was greater. So the capacity factor was increased and column capacity was high enough for preparation. Meanwhile, the higher specific recognition ability of the imprinted cavities to the imprinted molecule and enantiomers alike leads to the higher chiral cross-selectivity because of more ordered arrangement of the tribasic cross-linked MIP.