新型离子液体的合成及其在Heck反应合成烯丙醇类化合物中的应用

以甲基咪唑（或咪唑）和N-取代芳基-3-氯丙酰胺为原料，与KPF-6经离子交换制得6个新型酰胺基功能化离子液体（2a～2c和3a~3c）。以2-溴-6-甲氧基萘与烯丙醇反应为模板反应，2或3为反应介质，考察反应的转化率和区域选择性。结果表明： 3为反应介质时，转化率和区域选择性均高于2。以溴代芳烃和烯丙醇为原料，3c为反应介质，醋酸钯催化Heck反应制得2-取代芳烃烯丙醇化合物，收率85%~89％,立体选择性均大于99%。所得产物的结构均经¹H NMR, ¹³C NMR, IR, EI-MS和元素分析表征。

Synthesis of New Multifunctionalized Ionic Liquids and Their Application in Heck Reaction of Synthesizing Allyl Alcohols

Six new amide-multifunctionalized ionic liquids(2a～2c，3a~3c) were obtained by ion exchange of KPF-6 with 1-methyimidazole（or imidazole） and N-aryl-3-chlorobutanamide. The conversion and regioselectivities were investigated by the Heck reaction of 2-bromo-6-methoxynaphthylene with allyl alcohol using 2 or 3 as the medium. The results showed that the conversion and regioselectivities in 3 was better than in 2. Substituted aryl allyl alcohols were synthesized with high yields（85％～89%） and regioselectivities（＞99％） by Heck reaction of haloaryl compounds with allyl alcohol, using 3c as the medium and palladium acetate as the catalyst. The structures were characterized by ¹H NMR, ¹³C NMR, IR, EI-MS and elemental analysis.