Exercise-induced motor improvement after complete spinal cord transection and its relation to expression of brain-derived neurotrophic factor and presynaptic markers |
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| Authors: | Matylda Macias Dorota Nowicka Artur Czupryn Dorota Sulejczak Ma?gorzata Skup Jolanta Skangiel-Kramska Julita Czarkowska-Bauch |
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| Affiliation: | (1) Department of Neurophysiology, Nencki Institute of Experimental Biology, (3 Pasteur Str), (02-093) Warsaw, Poland;(2) Department of Molecular Neurobiology, Nencki Institute of Experimental Biology, (3 Pasteur Str), (02-093) Warsaw, Poland;(3) Department of Experimental Pharmacology, Medical, Research Centre, Polish Academy of Sciences, (5 Pawińskiego Str), (02-106) Warsaw, Poland;(4) Institute of Molecular and Cellular Biology, (4 Trojdena Str), (02-109) Warsaw, Poland |
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| Abstract: | ![]()
Background It has been postulated that exercise-induced activation of brain-derived neurotrophic factor (BDNF) may account for improvement of stepping ability in animals after complete spinal cord transection. As we have shown previously, treadmill locomotor exercise leads to up-regulation of BDNF protein and mRNA in the entire neuronal network of intact spinal cord. The questions arise: (i) how the treadmill locomotor training, supplemented with tail stimulation, affects the expression of molecular correlates of synaptic plasticity in spinal rats, and (ii) if a response is related to BDNF protein level and distribution. |
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