| 聚氧乙烯功能基复合修饰聚氨酯的合成及其血液相容性研究 (Ⅰ)──聚氨酯-接枝-十八烷基聚氧乙烯 |
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| 引用本文： | 计剑,季任天,邱永兴,陈宝林,封麟先.聚氧乙烯功能基复合修饰聚氨酯的合成及其血液相容性研究 (Ⅰ)──聚氨酯-接枝-十八烷基聚氧乙烯[J].高等学校化学学报,1999,20(5):814. |
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| 作者姓名： | 计剑 季任天 邱永兴 陈宝林 封麟先 |
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| 作者单位： | 浙江大学高分子科学与材料研究所, 杭州 310027 |
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| 摘 要： | 通过十八烷基聚氧乙烯和环氧氯丙烷的封端反应制备了α-环氧基-ω-十八烷基聚氧乙烯大单体.并采用BF3·Et2O引发THF和大单体共聚合,得到了梳状的十八烷基聚氧乙烯接枝共聚醚.以该共聚醚为软段合成了十八烷基和聚氧乙烯复合修饰的聚氨酯(PEU-g-PEO-C18).通过血小板粘附试验对材料的体外抗凝血性实验结果表明,采用具有选择性吸附白蛋白功能的十八烷基和PEO复合修饰聚氨酯,材料表面血小板粘附量明显减少.材料血液相容性的改善可能来源于疏水性的十八烷基和亲水性聚氧乙烯的协同作用.
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| 关 键 词： | 聚氨酯 白蛋白钝化 血液相容性 |
Synthesis and In vitro Blood-compatibility of Polyurethane Graft Stearyl Poly(ethylene oxide) |
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| JI Jian,JI Ren-Tian,QIU Yong-Xing,CHEN Bao-Lin,FENG Lin-Xian.Synthesis and In vitro Blood-compatibility of Polyurethane Graft Stearyl Poly(ethylene oxide)[J].Chemical Research In Chinese Universities,1999,20(5):814. |
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| Authors: | JI Jian JI Ren-Tian QIU Yong-Xing CHEN Bao-Lin FENG Lin-Xian |
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| Institution: | Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027 |
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| Abstract: | Anew grafted polyether, poly(tetramethylene glycol)-graft-ω-stearyl-poly(ethylene glycol)(PTMG-g-PEG-C18), was synthesized by the cationic polymerization of α-ω-bifunctional PEG macromonomer and THF. Polyurethane-graft-ω-stearyl poly(ethylene glycol)(PEU-g-PEO-C18), the new polyether as a soft segment, was synthesized. The results of platelet adhesion on PEU-g-PEG-C18surface indicated that the polyurethane can resist platelet adhesion on the original surface and pre adsorption albu min surface. |
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| Keywords: | Polyurethane Albu min Blood compatibility |
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