Spectrophotometric determination of trimethoprim by oxidation in drug formulations |
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| Authors: | S. Z. Qureshi M. I. H. Helaleh N. Rahman R. M. A. Q. Jamhour |
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| Affiliation: | (1) Analytical Research Laboratory, Department of Chemistry, Aligarh Muslim University, Aligarh-20 200 2, India (U. P.), IN |
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| Abstract: | A spectrophotometric determination of trimethoprim is described based on the reaction of its amine group with persulfate which acts as a strong oxidizing agent in alkaline media. The reaction produces a stable yellow colored compound after heating in a boiling water bath for 30 min. At λmax 355 nm, Beer’s law is obeyed in the concentration range 10–60 μg ml–1 with a molar absorptivity of 2.7 × 103 l mol–1cm–1. The method is applied to formulations with sulfamethoxazole. Received: 30 July 1996 / Revised: 16 October 1996 / Accepted: 22 October 1996 |
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