Chiral dihydrobenzofuran-based diphosphine (BICMAP): optical resolution and application to rhodium(I)-catalyzed asymmetric 1,4-addition of aryl- and alkenylboronic acids to cyclic enones |
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| Authors: | Takashi Mino Masatoshi HashimotoKatsunori Uehara Yoshiaki NaruseShohei Kobayashi Masami SakamotoTsutomu Fujita |
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| Institution: | Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, Chiba University, 1-33, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan |
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| Abstract: | Chiral dihydrobenzofuran-based diphosphine ligand (BICMAP) 1 was used as a ligand for the rhodium(I)-catalyzed asymmetric 1,4-addition of arylboronic acids to cyclic enones up to 99% ee. We also found that the BICMAP-rhodium system was an efficient catalyst for the 1,4-addition of alkenylboronic acids to 2-cyclohexenone in good enantioselectivities. |
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| Keywords: | Rhodium catalyst Diphosphine Asymmetric reaction 1 4-Addition |
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