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Halichonadins A-D, new sesquiterpenoids from a sponge Halichondria sp. |
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| Authors: | Haruaki Ishiyama Jane Fromont Yuzuru Mikami |
| Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku Kita 12, Jyou Nishi 6 Choume, Sapporo 060-0812, Japan b Western Australian Museum, Perth, WA 6000, Australia c Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan |
| Abstract: | A new dimeric sesquiterpenoid with two eudesmane skeletons through a urea linkage, halichonadin A (1), as well as three new eudesmane sesquiterpenoids having a carbamate, an isonitrile, or an amino functionality, halichonadins B (2), C (3), and D (4), respectively, have been isolated from a marine sponge Halichondria sp., and the gross structures and relative stereochemistry of 1-4 were elucidated on the basis of spectral data and chemical means. |
| Keywords: | Marine sponge Halichondria sp Sesquiterpenoid Halichonadin |
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