Contrast performance in catalytic ability—new cinchona phase transfer catalysts for asymmetric synthesis of α-amino acids |
| |
Authors: | Shanmugam Elango Murugapillai Venugopal P.S. Suresh Eni |
| |
Affiliation: | Institute of Chemical and Engineering Sciences, 1 Pesek road, Jurong Island 627833, Singapore |
| |
Abstract: | ![]() Two new cinchona phase transfer catalysts are prepared from dihydrocinchonidine using 13-picenylmethyl bromide and 1-pyrenylmethyl bromide, respectively. A total contrast in catalytic efficiency is observed during the asymmetric alkylation of glycinate esters; with one catalyst, the reaction is either incomplete or the enantioselectivity is very poor (15% ee) while the other catalyst afforded high selectivity up to 94% ee. |
| |
Keywords: | Chiral phase transfer catalyst Cinchona alkaloids |
本文献已被 ScienceDirect 等数据库收录! |