Highly efficient three-component Strecker-type reaction catalyzed by MgI2 etherate under solvent-free conditions |
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| Authors: | Pengcheng Li Yongdong Zhang Zhili Chen Xingxian Zhang |
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| Affiliation: | College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China |
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| Abstract: | A concise, straightforward and efficient method has been developed for the synthesis of α-aminonitriles by an one-pot three-component condensation of aldehydes or ketones, amines and trimethylsilyl cyanide catalyzed by MgI2 etherate under solvent-free conditions. This protocol has some advantages such as mild reaction condition, simple work-up, short reaction time and high product yields. |
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| Keywords: | Strecker reaction Aldehydes Ketones Amines Trimethylsilyl cyanide Solvent-free condition |
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