Atmospheric oxidative catalyst-free cross-dehydrogenative coupling of aldehydes with N-hydroxyimides |
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| Authors: | Xiaohe Xu Pingping Li Yingyi Huang Chuo Tong YiYan Yan Yuanyuan Xie |
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| Affiliation: | 1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, PR China;2. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China |
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| Abstract: | ![]()
Cross-dehydrogenative coupling (CDC) reactions of aldehydes with N-hydroxyimidates such as N-hydroxysuccinimide (NHSI), N-hydroxyphthalimide (NHPI) under catalyst-free conditions is described. Moreover, the desired products can be obtained simply by recrystallization from ethanol. This method is also applicable to the synthesis of amides in excellent yields. A radical mechanism of the type shown in Scheme 4 is proposed based upon the inhibition of the reaction in the presence of TEMPO. |
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| Keywords: | Catalyst-free Cross-dehydrogenative coupling Atmospheric oxidative Aldehydes Corresponding author at: Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, PR China. |
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