Synthesis of 1-arylcytosine-5-carboxylic acid esters |
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| Authors: | Dorokhov V A Voronkova V A Komkov A V Baranin S V Vasil’ev L S |
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| Institution: | 1.N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
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| Abstract: | A reaction of alkyl 2-(diaminomethylidene)-3-oxoalkanoates with arylisocyanates leads to the formation of the corresponding
ureas, which upon the action of Na alkoxides cyclize to 1-aryl-6-R-cytosine-5-carboxylates. The latter reacting with arylisocyanates
according to the similar scheme give rise to 3,6-diaryl-5-methylpyrimido4,5-d]pyrimidine-2,4,7(1H,3H,6H)-triones. |
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