ior egf/r3: A murine monoclonal antibody for diagnostic of epithelial tumors |
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| Authors: | M Ramos Suzarte N Rodríguez J P Oliva N Iznaga A Perera A Morales N Gonzalez O Torres T Rodríguez |
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| Institution: | (1) Center of Molecular Immunology, P.O.Box 16040, 11600 Havana, Cuba;(2) Center for Medical-Surgical Researches (CIMEQ), Calle 216 y 13, 11600 Havana, Cuba;(3) National Institute of Oncology and Radiobiology, 29 y E, Vedado, Havana, Cuba;(4) Center of Clinical Researches, Calle 45 y 34, No. 4501, Rpto Kohly, Havana, Cuba |
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| Abstract: | Monoclonal antibody ior egf/r3 is a IgG2a, recognizes the epidermal growth factor receptor. The aim of the present work was
to evaluate the diagnostic efficacy of the99mTc-labeled ior egf/r3 for the detection of epithelial tumors, its metastasis and its recurrences. The sensitivity by organs
was: brain 100%, diegestive tract 90%, head and neck 89%, lung 84% and breast 79%. The overall sensitivity, specificity, accuracy,
positive predictive value and negative predictive value of the immunoscintigraphic imaging were 84.1%, 100%, 86.5%, 100% and
52.4%, respectively. Immunoscintigraphy with99mTc-ior egf/r3 is useful for the diagnosis and follow-up of epithelial tumors. |
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