| 2,6-双(3′-溴甲基-1′-吡唑基)-4-溴吡啶的合成与表征 |
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| 引用本文： | 石竹,李宏涛,刘婷婷,潘利华,赫文龙.2,6-双(3′-溴甲基-1′-吡唑基)-4-溴吡啶的合成与表征[J].化学研究,2008,19(1). |
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| 作者姓名： | 石竹 李宏涛 刘婷婷 潘利华 赫文龙 |
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| 作者单位： | 1. 长春工业大学,生物工程学院,吉林,长春,130012
2. 长春应用化学研究所,国家电化学光谱分析研究中心,吉林,长春130022 |
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| 摘 要： | 以2,6-双(3′-甲基-1′-吡唑基)-4-氨基吡啶为原料,经重氮化,溴化合成了新型时间分辨荧光免疫分析双功能螯合剂中间体2,6-双(3′-溴甲基-1′-吡唑基)-4-溴吡啶.结构通过IR,MS,1H NMR和元素分析进行了表征,对合成条件进行了探讨.
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| 关 键 词： | 荧光免疫分析 2 6-双(3′-溴甲基-1′-吡唑基)-4-溴吡啶 螯合剂 |
Synthesis and Characterization of 2,6-Bis(3′-bromomethyl-pyrazol-1′-yl)-4-bromopyridine |
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| SHI Zhu,LI Hong-tao,LIU Ting-ting,PAN Li-hua,HE Wen-long.Synthesis and Characterization of 2,6-Bis(3′-bromomethyl-pyrazol-1′-yl)-4-bromopyridine[J].Chemical Research,2008,19(1). |
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| Authors: | SHI Zhu LI Hong-tao LIU Ting-ting PAN Li-hua HE Wen-long |
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| Abstract: | A new bifunctional chelate intermediate of time-resolved fluorescence immunoassay 2,6-bis(3′-bromomethyl-pyrazol-1′-yl)-4-bromopyridine was prepared from 2,6-bis(3′-methyl-1H-pyrazol-1′-yl)-4-aminopyridine by diazotization-Sandmeyer reaction and NBS reaction.The structure of the product was determined by IR,1H NMR,MS and element analysis.The reaction conditions were also researched. |
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| Keywords: | fluorescence immunoassay 2 6-bis(3′-bromomethyl-pyrazol-1′-yl)-4-bromopyridine chelate |
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