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| 双分子维生素B12模型分子的合成及钴氮键稳定性研究 | |
| 引用本文： | 冯亚青,张晓东,孟舒献,周立山. 双分子维生素B12模型分子的合成及钴氮键稳定性研究[J]. 高等学校化学学报, 2003, 24(6): 1031-1033 |
| 作者姓名： | 冯亚青 张晓东 孟舒献 周立山 |
| 作者单位： | 天津大学化工学院,碳一化学与化工国家重点实验室,天津,300072 |
| 基金项目： | 国家教育部优秀青年教师基金资助 |
| 摘 要： | 在合成单分子 B12 模型分子β-单腈 a,b,c,d,e,g-六甲基 -α- f- N - (3 -咪唑基 )丙酰胺钴啉酯高氯酸盐4f的基础上 [1～ 3 ] ,合成了双分子维生素 B12 模型分子 [4 ] ,为研究 B12 化学提供了一类新型的模型分子 ,并研究了 Co— N键的稳定性 .1 实验部分1 .1 仪器及原料 Pe |
| 关 键 词： | 维生素B12 双分子模型分子 紫外-可见光谱 平衡常数 |
| 文章编号： | 0251-0790(2003)06-1031-03 |
| 收稿时间： | 2002-07-01 |
Synthesis of a Dimer-VB12 Model Molecule and Stability of Co-N Bond |
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| FENG Ya-Qing ,ZHANG Xiao-Dong,MENG Shu-Xian,ZHOU Li-Shan. Synthesis of a Dimer-VB12 Model Molecule and Stability of Co-N Bond[J]. Chemical Research In Chinese Universities, 2003, 24(6): 1031-1033 | |
| Authors: | FENG Ya-Qing ZHANG Xiao-Dong MENG Shu-Xian ZHOU Li-Shan |
| Affiliation: | FENG Ya-Qing *,ZHANG Xiao-Dong,MENG Shu-Xian,ZHOU Li-Shan |
| Abstract: | Vitamin B 12 model molecule, dicyano cobyric mono acid hexamethylester 2f was synthesized from Vitamin B 12 by alcoholysis and acidic hydrolysis. Dicyano-a,b,c,d,e,g-α-f-N-(3-imidazoly) propylamido cobyrinate 3f was synthesized by the reaction between 2f and 3-imidazolylpropylamine hydrochloride. Compound 3f was treated with trifluoroacetic acid to give dimer-vitamin B 12 model molecule 5f. Compound 5f was treated with acidic buffers in methanol and the ring of 5f was opened to give compounds 6f. UV-Vis spectra were determined in buffers with different pH values. The equilibrium constants of Co-N bonds were calculated. K-value of 5f was 552×103, which is much greater than that of monomer vitamin B12 4f. The strength of coordination bonds between the N atom in the side chain of cobyrinate and the Co atom in 5f was much weaker than that in monomer-vitamin B12 4f. |
| Keywords: | Vitamin B 12 Dimer Model molecule UV-Vis spectrum Equilibrium constants |
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