A stereodivergent approach to substituted 4-hydroxypiperidines |
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| Authors: | Vink Mandy K S Schortinghuis Christien A Luten Jordy Van Maarseveen Jan H Schoemaker Hans E Hiemstra Henk Rutjes Floris P J T |
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| Institution: | Institute of Molecular Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, The Netherlands. |
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| Abstract: | A stereodivergent route toward both diastereomeric forms of functionalized 4-hydroxypiperidines has been successfully developed. This route involves biocatalytic generation of the enantiopure starting materials followed by functionalization via N-acyliminium ion-mediated CC-bond formation. |
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