|
|||||
|
|
In-water reactivity of nucleosides and nucleotides: one-step preparation and biological evaluation of novel ferrocenyl-derivatives |
|
| Authors: | Marcella de Champdoré ,Anna Messere,Gennaro Piccialli,Massimiliano La Colla |
| Affiliation: | a Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli ‘Federico II’, via Cynthia 4, 80126 Napoli, Italy b Dipartimento di Scienze Ambientali, Seconda Università di Napoli, via Vivaldi 43, 81100 Caserta, Italy c Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli ‘Federico II’, via D. Montesano 49, 80131 Napoli, Italy d Dipartimento di Scienze e Tecnologie Biomediche, Università di Cagliari, Cittadella Universitaria, SS 554, I-09042 Monserrato, Cagliari, Italy |
| Abstract: | The reactivity in water of a series of nucleosides and nucleotides towards ferrocenemethanol was investigated. Several adducts incorporating the ferrocenemethyl moiety into the heterocyclic base were isolated and their activity was tested against HIV-1, HBV, YFV, BVDV and several bacteria. However, none of the new compounds showed significant antiviral activity nor cytotoxicity. The reaction with ferrocenemethanol of the model dinucleotide 5′dCpdG3′, for a direct comparison of the behaviour of purine versus pyrimidine bases, is also discussed. |
| Keywords: | Nucleosides Nucleotides Ferrocene derivatives Biological activity |
| 本文献已被 ScienceDirect 等数据库收录！ | |