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Syntheses of ethyl 3-deoxy-3,3-difluoro-d-arabino-heptulosonate and analogues |
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| Authors: | Yuan Li Elizabeth V Welchman Shende Jiang Gurdial Singh |
| Affiliation: | a Department of Chemistry, University of Sunderland, Sunderland SR1 3SD, UK b Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK c High Force Research Ltd, Bowburn, Durham DH6 5PF, UK |
| Abstract: | The difluorinated analogues of 3-deoxy-d-arabino-heptulosonic acid (DAH) 12, 24 and its enantiomer have been synthesised from d- and l-erythrose via a Reformatsky reaction which gave a mixture of diastereoiosmers in favour of the anti isomer. |
| Keywords: | Reformatsky reaction Shikimate pathway Carbohydrate Fluorinated ulosonates Enzyme inhibitors |
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